1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Chemical Name:1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide
CAS No.:228259-42-5
Molecular Formula:C₂₆H₁₉F₄N₃O₅S
Molecular Weight:561.514
Hs Code.:

Synonyms:1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Chemical Property of 1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

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Technology Process of 1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

There total 7 articles about 1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(2'-methylsulfonyl)-3-fluoro-[1,1']-biphen-4-yl]amine

: 2-(5-chlorocarbonyl-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid methyl ester

: 228259-42-5
1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm030212h

Reference yield:

: 326-90-9
4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione

: 228259-42-5
1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 100 percent / 2 h / 20 °C

4: KMnO₄ / acetone; H₂O / 4 h / Heating

5: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

6: 3.34 g / DMAP / CH₂Cl₂ / 18 h / 20 °C

With dmap; potassium permanganate; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water; acetone;
DOI:10.1021/jm030212h

Reference yield:

: 5326-27-2
2-hydrazino-benzoic acid

: 228259-42-5
1-(2-methoxycarbonyl-phenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(3-fluoro-2'-methylsulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / glac. AcOH / 6 h / Heating

2: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 4 h

3: 100 percent / 2 h / 20 °C

4: KMnO₄ / acetone; H₂O / 4 h / Heating

5: oxalyl chloride / CH₂Cl₂ / 2 h / 20 °C

6: 3.34 g / DMAP / CH₂Cl₂ / 18 h / 20 °C

With dmap; potassium permanganate; oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water; acetone;
DOI:10.1021/jm030212h