4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester
CAS No.:1352721-51-7
Molecular Formula:C₃₇H₄₃ClN₆O₄
Molecular Weight:671.239
Hs Code.:

4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Synonyms:4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

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Technology Process of 4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1352721-52-8
4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

: 1352721-51-7
4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With tin(II) chloride dihdyrate; In ethanol; at 50 - 70 ℃; for 6h;

Reference yield:

: 79099-00-6
tert‐butyl 4‐((2‐aminophenyl)amino)piperidine‐1‐carboxylate

: 1352721-51-7
4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: water / acetonitrile / 22 h / 20 °C

2: potassium iodide / acetonitrile / 0.5 h / 20 - 110 °C / Sealed vessel

3: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

5: dmap / 1,2-dichloro-ethane / 5 h / 70 °C

6: tin(II) chloride dihdyrate / ethanol / 6 h / 50 - 70 °C

With tin(II) chloride dihdyrate; water; caesium carbonate; trifluoroacetic acid; potassium iodide; dmap; In ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 1352721-51-7
4-{3-[1-(2-amino-5-chloro-phenyl)-piperidin-4-yl]-2-[tert-butoxycarbonylimino]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap / acetonitrile / 16 h

1.2: 16 h

2.1: diisobutylaluminium hydride / cyclohexane; tetrahydrofuran / 16.33 h / -78 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C

3.2: 1.17 h / 0 °C

4.1: potassium iodide / acetonitrile / 0.5 h / 20 - 110 °C / Sealed vessel

5.1: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: dmap / 1,2-dichloro-ethane / 5 h / 70 °C

8.1: tin(II) chloride dihdyrate / ethanol / 6 h / 50 - 70 °C

With tin(II) chloride dihdyrate; carbon tetrabromide; water; diisobutylaluminium hydride; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium iodide; dmap; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;