4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester
CAS No.:1352721-52-8
Molecular Formula:C₃₇H₄₁ClN₆O₆
Molecular Weight:701.222
Hs Code.:

4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Synonyms:4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

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Technology Process of 4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

There total 11 articles about 4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1352721-53-9
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-3-(1H-indol-4-ylmethyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

: 1352721-52-8
4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: dmap; In 1,2-dichloro-ethane; at 70 ℃; for 5h;

Reference yield:

: 79099-00-6
tert‐butyl 4‐((2‐aminophenyl)amino)piperidine‐1‐carboxylate

: 1352721-52-8
4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: water / acetonitrile / 22 h / 20 °C

2: potassium iodide / acetonitrile / 0.5 h / 20 - 110 °C / Sealed vessel

3: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

5: dmap / 1,2-dichloro-ethane / 5 h / 70 °C

With water; caesium carbonate; trifluoroacetic acid; potassium iodide; dmap; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 1352721-52-8
4-{2-[tert-butoxycarbonylimino]-3-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-2,3-dihydro-benzoimidazol-1-ylmethyl}-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / acetonitrile / 16 h

1.2: 16 h

2.1: diisobutylaluminium hydride / cyclohexane; tetrahydrofuran / 16.33 h / -78 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 °C

3.2: 1.17 h / 0 °C

4.1: potassium iodide / acetonitrile / 0.5 h / 20 - 110 °C / Sealed vessel

5.1: trifluoroacetic acid; water / dichloromethane / 0.5 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: dmap / 1,2-dichloro-ethane / 5 h / 70 °C

With carbon tetrabromide; water; diisobutylaluminium hydride; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium iodide; dmap; In tetrahydrofuran; dichloromethane; cyclohexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;