Technology Process of (3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10, 11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one
There total 12 articles about (3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10, 11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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![(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)acetyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate](/Databaselist/images/loading.webp)
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1326312-08-6
(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)acetyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate
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1326312-09-7
(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10, 11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one
- Guidance literature:
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(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((tert-butoxycarbonyl)(4-chlorobenzyl)amino)acetyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl acetate;
With
hydrogenchloride; water;
In
1,4-dioxane;
at 20 ℃;
With
sodium hydrogencarbonate;
In
1,4-dioxane; water; ethyl acetate;
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1326312-09-7
(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10, 11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one
- Guidance literature:
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Multi-step reaction with 10 steps
1.1: acetic anhydride; hydrogen bromide; acetic acid / toluene / 1.5 h / 105 °C
2.1: acetic anhydride; sodium acetate; acetic acid; sodium dichromate dihydrate / toluene / 60 °C
3.1: potassium hydroxide / toluene; ethanol / 1 h / 20 °C
3.2: pH 7
4.1: silica gel; pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
5.1: triethylamine / dichloromethane / 20 °C
6.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0.5 h / 0 °C
7.1: zinc(II) chloride / methanol / 2 h / 20 °C
7.2: 2 h / 20 °C
8.1: triethylamine / 20 °C
9.1: silica gel; pyridinium chlorochromate / dichloromethane / 8 h / 20 °C
10.1: hydrogenchloride; water / 1,4-dioxane / 20 °C
With
hydrogenchloride; methanol; sodium tetrahydroborate; sodium dichromate dihydrate; nickel(II) chloride hexahydrate; water; hydrogen bromide; sodium acetate; acetic anhydride; silica gel; acetic acid; triethylamine; pyridinium chlorochromate; potassium hydroxide; zinc(II) chloride;
In
1,4-dioxane; methanol; ethanol; dichloromethane; toluene;
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1326312-09-7
(3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10, 11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one
- Guidance literature:
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Multi-step reaction with 11 steps
1.1: dmap; triethylamine / dichloromethane / Reflux
2.1: acetic anhydride; hydrogen bromide; acetic acid / toluene / 1.5 h / 105 °C
3.1: acetic anhydride; sodium acetate; acetic acid; sodium dichromate dihydrate / toluene / 60 °C
4.1: potassium hydroxide / toluene; ethanol / 1 h / 20 °C
4.2: pH 7
5.1: silica gel; pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
6.1: triethylamine / dichloromethane / 20 °C
7.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0.5 h / 0 °C
8.1: zinc(II) chloride / methanol / 2 h / 20 °C
8.2: 2 h / 20 °C
9.1: triethylamine / 20 °C
10.1: silica gel; pyridinium chlorochromate / dichloromethane / 8 h / 20 °C
11.1: hydrogenchloride; water / 1,4-dioxane / 20 °C
With
hydrogenchloride; methanol; dmap; sodium tetrahydroborate; sodium dichromate dihydrate; nickel(II) chloride hexahydrate; water; hydrogen bromide; sodium acetate; acetic anhydride; silica gel; acetic acid; triethylamine; pyridinium chlorochromate; potassium hydroxide; zinc(II) chloride;
In
1,4-dioxane; methanol; ethanol; dichloromethane; toluene;
