N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine

Base Information

• Chemical Name: N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine
• CAS No.: 372515-24-7
• Molecular Formula: C₄₆H₅₆N₇O₁₀P
• Molecular Weight: 897.965

Synonyms:N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine

Chemical Property of N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine

There total 8 articles about N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + N2-isobutyryl-9-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine (372515-48-5) → N2-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine (372515-24-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/1522-2675(20010613)84:6<1778::AID-HLCA1778>3.0.CO;2-3

Reference yield:

L-arabinofuranose (87-72-9,608-45-7,608-46-8,608-47-9,2460-44-8,6748-95-4,6763-34-4,7261-26-9,7283-06-9,7283-07-0,7296-55-1,7296-56-2,7296-58-4,7296-59-5,7296-60-8,7296-61-9,7296-62-0,7322-30-7,10257-31-5,10257-32-6,10257-33-7,10257-34-8,10257-35-9,19982-83-3,20242-88-0,28697-53-2,41546-41-2,89299-64-9,107655-34-5,115794-06-4,115794-07-5,130550-15-1,130606-21-2,36562-42-2) → N2-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine (372515-24-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 91.7 percent / pyridine / CH₂Cl₂ / 2.5 h

2: 58 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 21 h / 80 °C

3: 79 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 0 °C

4: 66 percent / TMS-Cl / dimethylformamide / 16 h / 20 °C

5: 2,6-lutidine / CH₂Cl₂ / 120 h / 4 °C

6: aq. AcOH / CH₂Cl₂; tetrahydrofuran / 13 h / 20 °C

7: 70 percent / EtN(i-Pr)2 / CH₂Cl₂ / 20 °C

With pyridine; 2,6-dimethylpyridine; sodium hydroxide; chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(20010613)84:6<1778::AID-HLCA1778>3.0.CO;2-3

Reference yield:

1',2',3',4'-tetra-O-benzoyl-L-lyxopyranose (372515-38-3) → N2-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine (372515-24-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 58 percent / N,O-bis(trimethylsilyl)acetamide; trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 21 h / 80 °C

2: 79 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 0 °C

3: 66 percent / TMS-Cl / dimethylformamide / 16 h / 20 °C

4: 2,6-lutidine / CH₂Cl₂ / 120 h / 4 °C

5: aq. AcOH / CH₂Cl₂; tetrahydrofuran / 13 h / 20 °C

6: 70 percent / EtN(i-Pr)2 / CH₂Cl₂ / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; chloro-trimethyl-silane; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(20010613)84:6<1778::AID-HLCA1778>3.0.CO;2-3

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

N²-isobutyryl-9-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine

L-arabinofuranose

1',2',3',4'-tetra-O-benzoyl-L-lyxopyranose

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 372515-24-7 N²-isobutyryl-9-{3'-O-acetyl-2'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-α-L-lyxopyranosyl}guanine

Send

Send

Metric Ton KG G Pound L ML

Send

Send