2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

Base Information

Chemical Name:2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde
CAS No.:1603163-98-9
Molecular Formula:C₂₁H₁₈O₂
Molecular Weight:302.373
Hs Code.:

Synonyms:2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

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Chemical Property of 2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

Chemical Property:

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Technology Process of 2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

There total 6 articles about 2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1603164-07-3
2-(2-((4-Methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-ethanol

: 1603163-98-9
2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

Guidance literature:: With pyridine; Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/jo500561z

Reference yield:

: C₂₀H₂₆BBr

: 1603163-98-9
2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium perborate tetrahydrate / tetrahydrofuran / 1.17 h / Reflux

2.1: palladium diacetate; triphenylphosphine; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 24 h / 90 °C

3.1: Dess-Martin periodane; pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; sodium perborate tetrahydrate; water; palladium diacetate; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling;
DOI:10.1021/jo500561z

Reference yield:

: 112631-07-9
2-bromo-3,4-dihydro-1-naphthaldehyde

: 1603163-98-9
2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C

1.2: 2 h / 0 °C

2.1: tetrahydrofuran / 24 h / Reflux

3.1: water; sodium perborate tetrahydrate / tetrahydrofuran / 1.17 h / Reflux

4.1: palladium diacetate; triphenylphosphine; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 24 h / 90 °C

5.1: Dess-Martin periodane; pyridine / dichloromethane / 1 h / 0 - 20 °C

With pyridine; sodium perborate tetrahydrate; potassium tert-butylate; water; palladium diacetate; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 1.1: |Wittig Olefination / 4.1: |Sonogashira Cross-Coupling / 4.2: |Sonogashira Cross-Coupling;
DOI:10.1021/jo500561z