1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

Base Information

Chemical Name:1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one
CAS No.:1603163-92-3
Molecular Formula:C₂₃H₂₀O₂
Molecular Weight:328.411
Hs Code.:

Synonyms:1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

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Chemical Property of 1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

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Technology Process of 1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

There total 8 articles about 1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1603163-82-1
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

: 1603163-92-3
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 17h; Reflux;
DOI:10.1021/jo500561z

Reference yield:

: C₂₀H₂₆BBr

: 1603163-92-3
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium perborate tetrahydrate / tetrahydrofuran / 1.17 h / Reflux

2.1: palladium diacetate; triphenylphosphine; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 24 h / 90 °C

3.1: Dess-Martin periodane; pyridine / dichloromethane / 1 h / 0 - 20 °C

4.1: tetrahydrofuran / 0.5 h / 0 °C

5.1: manganese(IV) oxide / dichloromethane / 17 h / Reflux

With pyridine; manganese(IV) oxide; sodium perborate tetrahydrate; water; palladium diacetate; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling / 4.1: |Grignard Reaction;
DOI:10.1021/jo500561z

Reference yield:

: 1603163-98-9
2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

: 1603163-92-3
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 0 °C

2: manganese(IV) oxide / dichloromethane / 17 h / Reflux

With manganese(IV) oxide; In tetrahydrofuran; dichloromethane; 1: |Grignard Reaction;
DOI:10.1021/jo500561z