O,O′-diphenyl S-hydrogen phosphorothioate

Base Information

• Chemical Name: O,O′-diphenyl S-hydrogen phosphorothioate
• CAS No.: 14156-07-1
• Molecular Formula: C₁₂H₁₁O₃PS
• Molecular Weight: 266.257
• Mol file: 14156-07-1.mol

Synonyms:O,O′-diphenyl S-hydrogen phosphorothioate

Chemical Property of O,O′-diphenyl S-hydrogen phosphorothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O,O′-diphenyl S-hydrogen phosphorothioate

There total 15 articles about O,O′-diphenyl S-hydrogen phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

diphenyl hydrogen phosphite (4712-55-4) → O,O′-diphenyl S-hydrogen phosphorothioate (14156-07-1)

Guidance literature:

With sulfur; triethylamine; In diethyl ether; for 3h; Reflux;

DOI:10.1055/s-0036-1588612

Reference yield: 40.0%

carbon disulfide (75-15-0,12122-00-8) + diphenyl hydrogen phosphite (4712-55-4) → diphenylthiophosphoric acid (14156-07-1) + Methandiphosphonsaeuretetraphenylester (84441-53-2)

Guidance literature:

diphenyl hydrogen phosphite; With sodium hydride; In tetrahydrofuran; at -5 - 20 ℃; Inert atmosphere;

carbon disulfide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1080/10426500802715528

Reference yield:

O,O′-diphenyl S-(4-oxo-4-phenylbutan-2-yl) phosphorothioate → (E)-1-phenyl-2-buten-1-one (35660-91-4,35845-66-0,495-41-0) + O,O′-diphenyl S-(4-oxo-4-phenylbutan-2-yl) phosphorothioate + O,O′-diphenyl S-(4-oxo-4-phenylbutan-2-yl) phosphorothioate + O,O′-diphenyl S-hydrogen phosphorothioate (14156-07-1)

Guidance literature:

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-{(S)[(2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl]-(6-methoxy-4-quinolinyl)methyl}thiourea; sodium hydrogencarbonate; In water; toluene; at 20 ℃; for 24h; Optical yield = < 1 %ee; Resolution of racemate;

DOI:10.1055/s-0036-1588612

upstream raw materials:

O,O,O-triphenyl phosphorothioate

O,O-diphenyl phosphorochloridothioate

2-ethoxy-ethanol

O,O-diphenyl O-n-propyl phosphorothionate

Downstream raw materials:

2-oxo-2-phenoxy-4,5-dimethyl-1,3,2-thiaozaphospholane

N-(diphenylphosphoryl)-N,N'-dibenzylurea

(3aR,5S,6S,6aR)-2,2-Dimethyl-5-((S)-2-oxo-2-phenoxy-2λ⁵-[1,3,2]oxathiaphospholan-5-yl)-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol

Thiophosphoric acid S-[(S)-2-hydroxy-2-((3aR,5S,6S,6aR)-6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl] ester O,O'-diphenyl ester