(1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

Base Information

Chemical Name:(1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one
CAS No.:133661-18-4
Molecular Formula:C₁₇H₂₀Cl₂O₂
Molecular Weight:327.251
Hs Code.:

Synonyms:(1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

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Chemical Property of (1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

Chemical Property:

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Technology Process of (1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

There total 5 articles about (1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133661-17-3
(1SR,5SR)-1-benzyloxy-4,5-dimethylcyclohex-3-ene

: 76-02-8
trifluoroacetyl chloride

: 133661-18-4
(1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

Guidance literature:: With copper; zinc; trichlorophosphate; In diethyl ether; Heating;
DOI:10.1016/S0040-4039(00)74881-7

Reference yield:

: 133661-15-1
4,5-dimethyl-3-cyclohexen-1-one

: 133661-18-4
(1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: LS-Selectride / tetrahydrofuran / -100 °C

2: 98 percent / NaH; N-Bu₄NI / tetrahydrofuran / 2 h / Heating

3: POCl₃; Zn-Cu / diethyl ether / 16 h / 20 °C

With tetra-(n-butyl)ammonium iodide; copper; sodium hydride; lithium tri-sec-butyl(hydrido)borate; zinc; trichlorophosphate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja0208456

Reference yield:

: 133661-16-2,151433-56-6
(1SR,5SR)-4,5-dimethylcyclohex-3-en-1-ol

: 133661-18-4
(1R,2S,4R,6S)-4-Benzyloxy-8,8-dichloro-1,2-dimethyl-bicyclo[4.2.0]octan-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NaH; N-Bu₄NI / tetrahydrofuran / 2 h / Heating

2: POCl₃; Zn-Cu / diethyl ether / 16 h / 20 °C

With tetra-(n-butyl)ammonium iodide; copper; sodium hydride; zinc; trichlorophosphate; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja0208456