benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

Base Information

Chemical Name:benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate
CAS No.:1629149-57-0
Molecular Formula:C₃₉H₄₂NO₁₀P
Molecular Weight:715.737
Hs Code.:

Synonyms:benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

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Chemical Property of benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

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Technology Process of benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

There total 3 articles about benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 53064-79-2
iodomethyl pivaloate

: 1610355-13-9
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine [phenylmethyl hydrogen Phosphate (ester)]phenylmethyl ester

: 1629149-57-0
benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/cbdv.201300202

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1629149-57-0
benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201300202

Reference yield:

: 175291-56-2
Fmoc-L-Thr(HPO₃Bzl)-OH

: 1629149-57-0
benzyl O-[(benzyloxy){[(2,2-dimethylpropanoyl)oxy]methoxy}phosphoryl]-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-threoninate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201300202