9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R),4,4a(R),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

Base Information

Chemical Name:9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol
CAS No.:78167-04-1
Molecular Formula:C₂₄H₂₉NO₅
Molecular Weight:411.498
Hs Code.:

Synonyms:9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

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Chemical Property of 9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

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Technology Process of 9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

There total 40 articles about 9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 78167-03-0,80754-85-4
9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,4,4a(R*),9b(R*)-tetrahydro-6-methoxy-3(2H)-dibenzofuranone

: 78167-04-1
9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

Guidance literature:: With L-Selectride; In tetrahydrofuran; 1.) -78 deg C, 2 h, 2.) 0 deg C, 2 h;
DOI:10.1021/jo00347a029

Reference yield:

: 23343-06-8
2-allyloxy-3-methoxy-benzaldehyde

: 78167-04-1
9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

Guidance literature:: Multi-step reaction with 7 steps

2: pyridinium dichromate / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) RT, 4 h

4: 1N HCl / 6 h / Ambient temperature

5: 10percent KOH / methanol / 2 h / Ambient temperature

6: 86 percent / rhodium trichloride trihydrate / ethanol / 8 h / Heating

7: 88 percent / L-Selectride / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 0 deg C, 2 h

With hydrogenchloride; potassium hydroxide; rhodium(III) chloride; dipyridinium dichromate; L-Selectride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00347a029

Reference yield:

: 78166-99-1
1-<2-(allyloxy)-3-methoxyphenyl>-3-<(carbobenzyloxy)-methylamino>propan-1-one

: 78167-04-1
9b-<2-<(carbobenzyloxy)methylamino>ethyl>-1,2,3(R*),4,4a(R*),9b(R*)-hexahydro-6-methoxy-3-dibenzofuranol

Guidance literature:: Multi-step reaction with 6 steps

1: n-butyllithium / tetrahydrofuran / 2 h / Heating

2: 2.) HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, RT

3: 1N HCl / 6 h / Ambient temperature

4: 10percent KOH / methanol / 2 h / Ambient temperature

5: 86 percent / rhodium trichloride trihydrate / ethanol / 8 h / Heating

6: 88 percent / L-Selectride / tetrahydrofuran / 1.) -78 deg C, 2 h, 2.) 0 deg C, 2 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; rhodium(III) chloride; n-butyllithium; L-Selectride; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jo00347a029