(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

Base Information

Chemical Name:(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite
CAS No.:1447720-84-4
Molecular Formula:C₄₆H₅₁N₄O₆P
Molecular Weight:786.908
Hs Code.:

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

Synonyms:(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

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Chemical Property of (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

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Technology Process of (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

There total 7 articles about (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1447721-11-0
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-ol

: 133485-25-3
bis(diisopropylamino)(2-cyanoethoxy)phosphane

: 1447720-84-4
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja311434s

Reference yield:

: 1447720-48-0
((2R,3S,5R)-3-((4-methylbenzoyl)oxy)-5-(1H-perimidin-1-yl)tetrahydrofuran-2-yl)methyl 4-methylbenzoate

: 1447720-84-4
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / tetrahydrofuran; methanol / 2 h / 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: pyridine / 16 h / 25 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 25 °C / Inert atmosphere

With pyridine; sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja311434s

Reference yield:

: 204-02-4
1-H-perimidine

: 1447720-84-4
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(1H-perimidin-1-yl)tetrahydrofuran-3-yl(cyanomethyl) diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: sodium methylate / tetrahydrofuran; methanol / 2 h / 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: pyridine / 16 h / 25 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 25 °C / Inert atmosphere

With pyridine; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja311434s