ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

Base Information

Chemical Name:ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate
CAS No.:1415797-72-6
Molecular Formula:C₁₆H₁₅FN₂O₅S
Molecular Weight:366.37
Hs Code.:

Synonyms:ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

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Chemical Property of ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

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Technology Process of ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

There total 3 articles about ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: 1378728-45-0
ethyl 5-(4-fluorophenylamino)thiazole-4-formate

: 1415797-72-6
ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

Guidance literature:: In 1,2-dichloro-ethane; for 2h; Reflux;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1415797-72-6
ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

3: 1,2-dichloro-ethane / 2 h / Reflux

With potassium tert-butylate; triethylamine; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield:

: 1544-68-9
4-fluorophenyl isothiocyanate

: 1415797-72-6
ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

2: 1,2-dichloro-ethane / 2 h / Reflux

With potassium tert-butylate; In tetrahydrofuran; 1,2-dichloro-ethane;