methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

Base Information

Chemical Name:methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate
CAS No.:934586-57-9
Molecular Formula:C₃₅H₃₆N₂O₈S
Molecular Weight:644.745
Hs Code.:

Synonyms:methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

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Chemical Property of methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

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Technology Process of methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

There total 7 articles about methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915706-91-1
2-(1-tosyl-1H-indol-3-yl)acetyl chloride

: 915706-92-2
3-[3-{2-benzyloxyethyl}-2-oxo-piperidin-3-yl]-3-oxo-propionic acid methyl ester

: 934586-57-9
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

Guidance literature:: With 4 A molecular sieve; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ol062029z

Reference yield:

: 915707-07-2
3-(2-benzyloxyethyl)-2-oxopiperidine-3-carboxylic acid

: 934586-57-9
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 20 °C

2: 8.9 g / magnesium chloride; 4-(dimethylamino)pyridine; triethylamine / tetrahydrofuran; acetonitrile / 20 °C

3: 8.1 g / molecular sieves 4 Angstroem / tetrahydrofuran / 12 h / 20 °C

With dmap; 4 A molecular sieve; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2007.01.064

Reference yield:

: 915707-06-1
3-(2-benzyloxyethyl)-2-oxopiperidine-3-carboxylic acid ethyl ester

: 934586-57-9
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / potassium hydroxide; H₂O / tetrahydrofuran

2: CH₂Cl₂ / 20 °C

3: 8.9 g / magnesium chloride; 4-(dimethylamino)pyridine; triethylamine / tetrahydrofuran; acetonitrile / 20 °C

4: 8.1 g / molecular sieves 4 Angstroem / tetrahydrofuran / 12 h / 20 °C

With dmap; potassium hydroxide; 4 A molecular sieve; water; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2007.01.064