methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

Base Information

Chemical Name:methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate
CAS No.:934586-52-4
Molecular Formula:C₃₅H₃₄N₄O₈S
Molecular Weight:670.743
Hs Code.:

Synonyms:methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

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Chemical Property of methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

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Technology Process of methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

There total 10 articles about methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 934586-57-9
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)piperidin-3-yl)-3-oxo-propanoate

: 934586-52-4
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1021/ol062029z

Reference yield:

: 915706-92-2
3-[3-{2-benzyloxyethyl}-2-oxo-piperidin-3-yl]-3-oxo-propionic acid methyl ester

: 934586-52-4
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 8.1 g / molecular sieves 4 Angstroem / tetrahydrofuran / 12 h / 20 °C

2: 88 percent / mesyl azide; triethylamine / acetonitrile / 5 h / 20 °C

With 4 A molecular sieve; triethylamine; Methanesulfonyl azide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.tet.2007.01.064

Reference yield:

: 128742-77-8
[N-(p-toluenesulfonyl)indol-3-yl]acetic acid

: 934586-52-4
methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2; DMF / CH₂Cl₂ / 4 h / 20 °C

2: 8.1 g / molecular sieves 4 Angstroem / tetrahydrofuran / 12 h / 20 °C

3: 88 percent / mesyl azide; triethylamine / acetonitrile / 5 h / 20 °C

With oxalyl dichloride; 4 A molecular sieve; triethylamine; N,N-dimethyl-formamide; Methanesulfonyl azide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2007.01.064