benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

Base Information

Chemical Name:benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate
CAS No.:147610-86-4
Molecular Formula:C₂₀H₂₈N₂O₄
Molecular Weight:360.453
Hs Code.:

Synonyms:benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

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Chemical Property of benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

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Technology Process of benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

There total 5 articles about benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 147610-85-3
6-(benzyloxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 147610-86-4
benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; for 6h; Reagent/catalyst; Concentration; Reflux;

Reference yield:

: 1419221-95-6
6-benzyl 1-methyl 6-azaspiro[2.5]octane-1,6-dicarboxylate

: 147610-86-4
benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 6 h / Reflux

2.2: Reflux

With diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; toluene;

Reference yield:

: benzyl 1-((4S,5R)-4-methyl-2-oxo-5-phenyloxazolidine-3-carbonyl)-6-azaspiro[2.5]octane-6-carboxylate

: 147610-86-4
benzyl 1-(tert-butoxycarbonylamino)-6-azaspiro[2.5]octane-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 16 h / 20 °C

2: diphenyl phosphoryl azide; triethylamine / 6 h / Reflux

With diphenyl phosphoryl azide; water; dihydrogen peroxide; triethylamine; lithium hydroxide; In tetrahydrofuran;