2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Chemical Name:2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide
CAS No.:1394939-93-5
Molecular Formula:C₂₅H₂₁F₂N₃O₃S₂
Molecular Weight:513.589
Hs Code.:

Synonyms:2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Chemical Property of 2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

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Technology Process of 2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

There total 9 articles about 2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1394939-91-3
3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]aniline

: 60230-36-6
2,6-difluorobenzene-1-sulfonyl chloride

: 1394939-93-5
2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/cmdc.201402424

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1394939-93-5
2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 2 h / Reflux

2: sodium acetate; bromine; acetic acid / 48 h / 20 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

4: sodium acetate; zinc; acetic acid / ethanol / 3 h / Reflux

5: pyridine / dichloromethane / 2 h / 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bromine; sodium acetate; caesium carbonate; acetic acid; zinc; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1002/cmdc.201402424

Reference yield:

: 110238-91-0
tetrahydropyran-4-carboxylic acid methyl ester

: 1394939-93-5
2,6-difluoro-N-{3-[5-(pyridin-4-yl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium hydroxide / 18 h / 20 °C

2: tetrahydrofuran / 4 h / Reflux

3: ethanol / 2 h / Reflux

4: sodium acetate; bromine; acetic acid / 48 h / 20 °C

5: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

6: sodium acetate; zinc; acetic acid / ethanol / 3 h / Reflux

7: pyridine / dichloromethane / 2 h / 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; bromine; sodium acetate; caesium carbonate; acetic acid; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Lawesson Thiocarbonylation;
DOI:10.1002/cmdc.201402424