trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

Base Information

Chemical Name:trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate
CAS No.:945997-28-4
Molecular Formula:C₂HF₃O₂*C₃₂H₃₀ClF₃N₂O₃S
Molecular Weight:729.14
Hs Code.:

trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

Synonyms:trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

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Chemical Property of trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

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Technology Process of trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

There total 7 articles about trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 945997-14-8
trans-tert-butyl {4-[(3-chloro-benzo[b]thiophene-2-carbonyl)-(4'-cyano-4-methoxy-biphenyl-5-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate

: 945997-28-4
trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 945997-28-4
trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / tetrahydrofuran; methanol; toluene / 4 h / 20 °C

1.2: 1 h

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 0.5 - 1.5 h / 80 - 120 °C / microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 566172-78-9
n-butyl trans-(4-aminocyclohexyl)-carbamate

: 945997-28-4
trans-3-chloro-benzo[b]thiophene-2-carboxylic acid [4-methoxy-4'-(2,2,2-trifluoro-acetyl)-biphenyl-3-ylmethyl]-(4-methylamino-cyclohexyl)-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 18.5 h / 0 °C / Heating / reflux

1.2: 2.16 h / 0 - 20 °C

2.1: benzaldehyde / toluene / 6 h / Heating / reflux

2.2: 3.25 h / 20 °C

3.1: acetic acid / tetrahydrofuran; methanol; toluene / 4 h / 20 °C

3.2: 1 h

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 0.5 - 1.5 h / 80 - 120 °C / microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; caesium carbonate; benzaldehyde; acetic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; toluene; 4.1: Suzuki Coupling;