2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

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Chemical Name:2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol
CAS No.:1307810-12-3
Molecular Formula:C₂₆H₂₅F₃N₄O₂
Molecular Weight:482.505
Hs Code.:

Synonyms:2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

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Chemical Property of 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

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Technology Process of 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

There total 8 articles about 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.5%

: 1307813-13-3
ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

: 1307810-12-3
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

Guidance literature:: With sodium tetrahydroborate; ethanol; at 20 ℃; for 19h;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307810-12-3
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 1.48 h / 0 °C / Cooling with ice

4.3: 0.5 h / 20 - 100 °C / Inert atmosphere

5.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

5.2: 5 h / 40 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogenchloride / diethyl ether; water / 0.5 h / 20 °C

8.1: ethanol; sodium tetrahydroborate / 19 h / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; dimethyl sulfoxide;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307810-12-3
2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[ 1,2-c]isoxazol-7-yl)butan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 1.48 h / 0 °C / Cooling with ice

3.3: 0.5 h / 20 - 100 °C / Inert atmosphere

4.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

4.2: 5 h / 40 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride / diethyl ether; water / 0.5 h / 20 °C

7.1: ethanol; sodium tetrahydroborate / 19 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; ethanol; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; dimethyl sulfoxide;