3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Base Information

Chemical Name:3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole
CAS No.:1307813-10-0
Molecular Formula:C₂₃H₁₆F₃N₃O
Molecular Weight:407.395
Hs Code.:

Synonyms:3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

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Chemical Property of 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

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Technology Process of 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

There total 4 articles about 3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.1%

: 1307812-05-0
6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime

: 112055-34-2
ethyl 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1307813-10-0
3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Guidance literature:: 6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

ethyl 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; In tetrahydrofuran; at 0 ℃; for 1.48333h; Cooling with ice;

With pyridine; thionyl chloride; In toluene; at 20 - 100 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307813-10-0
3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 1.48 h / 0 °C / Cooling with ice

4.3: 0.5 h / 20 - 100 °C / Inert atmosphere

With pyridine; hydroxylamine hydrochloride; sodium acetate; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307813-10-0
3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 1.48 h / 0 °C / Cooling with ice

3.3: 0.5 h / 20 - 100 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium acetate; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol;