ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

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Chemical Name:ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate
CAS No.:1307813-13-3
Molecular Formula:C₂₈H₂₇F₃N₄O₃
Molecular Weight:524.543
Hs Code.:

Synonyms:ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

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Chemical Property of ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

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Technology Process of ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

There total 7 articles about ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1307813-12-2
ethyl 2-(diphenylmethyleneamino)-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

: 1307813-13-3
ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

Guidance literature:: With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 0.5h;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307813-13-3
ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 1.48 h / 0 °C / Cooling with ice

4.3: 0.5 h / 20 - 100 °C / Inert atmosphere

5.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

5.2: 5 h / 40 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogenchloride / diethyl ether; water / 0.5 h / 20 °C

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; dimethyl sulfoxide;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307813-13-3
ethyl 2-amino-2-methyl-4-(3-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 1.48 h / 0 °C / Cooling with ice

3.3: 0.5 h / 20 - 100 °C / Inert atmosphere

4.1: caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

4.2: 5 h / 40 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride / diethyl ether; water / 0.5 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; water; dimethyl sulfoxide;