[(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

Base Information

Chemical Name:[(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid
CAS No.:174961-54-7
Molecular Formula:C₂₁H₃₀N₂O₅
Molecular Weight:390.48
Hs Code.:

Synonyms:[(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

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Chemical Property of [(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

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Technology Process of [(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

There total 8 articles about [(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74411-97-5
3(S)-[(tert-butyloxycarbonyl)amino]-2-oxo-1-piperidineacetic acid

: 174961-54-7
[(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / K₂CO₃ / dimethylformamide; acetonitrile / Heating

2: 100 percent / 5 N aq. HCl / ethyl acetate / 3 h / Ambient temperature

3: 70 percent / Na(OAc)3BH, Et₃N, DCE / Ambient temperature

4: NaHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

5: LiN(TMS)2 / tetrahydrofuran / 0 - 20 °C

6: 96 percent / HCl / ethanol / 0 - 20 °C

7: 69 percent / Na(OAc)3BH, Et₃N / Ambient temperature

8: 1.) NaHCO₃, 2.) aq. LiOH, 3.) Dowex H⁺

With hydrogenchloride; lithium hydroxide; DCE; Dowex H⁺; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(98)00636-2

Reference yield:

: 95582-22-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-hexahydro-1H-azepine-1-acetic acid,ethyl ester

: 174961-54-7
[(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / HCl / ethanol / 0 - 20 °C

2: 69 percent / Na(OAc)3BH, Et₃N / Ambient temperature

3: 1.) NaHCO₃, 2.) aq. LiOH, 3.) Dowex H⁺

With hydrogenchloride; lithium hydroxide; Dowex H⁺; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; In ethanol;
DOI:10.1016/S0960-894X(98)00636-2

Reference yield:

: 175133-83-2,1256385-95-1
(3S)-benzyl 2-(3-((tert-butoxycarbonyl)amino)-2-oxopiperidin-1-yl)acetate

: 174961-54-7
[(S)-3-(tert-Butoxycarbonyl-phenethyl-amino)-2-oxo-azepan-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / 5 N aq. HCl / ethyl acetate / 3 h / Ambient temperature

2: 70 percent / Na(OAc)3BH, Et₃N, DCE / Ambient temperature

3: NaHCO₃ / tetrahydrofuran; H₂O / 1.5 h / Ambient temperature

4: LiN(TMS)2 / tetrahydrofuran / 0 - 20 °C

5: 96 percent / HCl / ethanol / 0 - 20 °C

6: 69 percent / Na(OAc)3BH, Et₃N / Ambient temperature

7: 1.) NaHCO₃, 2.) aq. LiOH, 3.) Dowex H⁺

With hydrogenchloride; lithium hydroxide; DCE; Dowex H⁺; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1016/S0960-894X(98)00636-2