3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

Base Information

Chemical Name:3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid
CAS No.:1609286-92-1
Molecular Formula:C₁₈H₁₉F₂NO₃S
Molecular Weight:367.417
Hs Code.:

Synonyms:3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

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Chemical Property of 3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

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Technology Process of 3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

There total 9 articles about 3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1609290-31-4
3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid ethyl ester

: 1609286-92-1
3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: 1609289-02-2
(E)-3-(4-benzyloxy-3,5-difluorophenyl)acrylic acid ethyl ester

: 1609286-92-1
3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C

2: caesium carbonate / acetonitrile / 1 h / 80 - 85 °C

3: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; acetonitrile;

Reference yield:

: 118276-06-5
3,5-difluoro-4-hydroxybenzaldehyde

: 1609286-92-1
3-[3,5-difluoro-4-(2-isopropylsulfanylpyridin-3-ylmethoxy)phenyl]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / acetonitrile / 2 h / 0 - 20 °C

2: tetrahydrofuran / 1 h / 65 - 75 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C

4: caesium carbonate / acetonitrile / 1 h / 80 - 85 °C

5: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With palladium 10% on activated carbon; water; hydrogen; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; acetonitrile;