N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

Base Information

Chemical Name:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester
CAS No.:101810-77-9
Molecular Formula:C₂₄H₂₉N₇O₅
Molecular Weight:495.538
Hs Code.:

Synonyms:N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

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Chemical Property of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

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Technology Process of N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

There total 4 articles about N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101810-75-7
6-(bromomethyl)-2,4-diamino-5-methylpyrido<2,3-d>pyrimidine hydrobromide

: 101810-76-8
N-<4-(methylamino)benzoyl>-L-glutamic acid dimethyl ester

: 101810-77-9
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

Guidance literature:: In N,N-dimethyl acetamide; Yield given; 1.) 22 deg C - 25 deg C, 24 h, 2.) 50 deg C - 55 deg C, 4 h, 3.) 23 deg C - 25 deg C, 16 h;
DOI:10.1021/jm00156a029

Reference yield:

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 101810-77-9
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent

2: 90 percent / H₂ / 30percent Pd/C / methanol / 2 h / 20 °C / 760 Torr

3: N,N-dimethyl-acetamide / 1.) 22 deg C - 25 deg C, 24 h, 2.) 50 deg C - 55 deg C, 4 h, 3.) 23 deg C - 25 deg C, 16 h

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00156a029

Reference yield:

: 66891-86-9
benzyl (4-(chlorocarbonyl)phenyl)(methyl)carbamate

: 101810-77-9
N-<4-<<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>methylamino>benzoyl>-L-glutamic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent

2: 90 percent / H₂ / 30percent Pd/C / methanol / 2 h / 20 °C / 760 Torr

3: N,N-dimethyl-acetamide / 1.) 22 deg C - 25 deg C, 24 h, 2.) 50 deg C - 55 deg C, 4 h, 3.) 23 deg C - 25 deg C, 16 h

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00156a029