2-Amino-4chlorobenzenesulfonic acid

Base Information

• Chemical Name: 2-Amino-4chlorobenzenesulfonic acid
• CAS No.: 3479-10-5
• Molecular Formula: C6H6 Cl N O3 S
• Molecular Weight: 207.638
• Hs Code.: 2921420090
• Mol file: 3479-10-5.mol

Synonyms:2-Amino-4-chlorobenzenesulfonicacid; 3-Chloroaniline-6-sulfonic acid; NSC 36942

Chemical Property of 2-Amino-4chlorobenzenesulfonic acid

Chemical Property:

• PSA: 88.77000
• Density: 1.642g/cm³
• LogP: 2.83090

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4chlorobenzenesulfonic acid

There total 9 articles about 2-Amino-4chlorobenzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-chlorobenzo[d]thiazole (2786-51-8) → 1-amino-3-chlorobenzene-6-sulfonic acid (3479-10-5)

Guidance literature:

With [RuCl(P(C₆H₅)3)2(O(C₆H₄)NCH(C₄H₃N))]; bromamine B; sodium hydroxide; In water; acetonitrile; at 39.84 ℃; for 5.58333h;

DOI:10.1016/j.molcata.2010.06.006

Reference yield: 90.0%

3-chloroaniline hydrogen sulfate → 1-amino-3-chlorobenzene-6-sulfonic acid (3479-10-5)

Guidance literature:

In 1,1,2,2-tetrachloroethane; at 200 ℃; for 1.5h; Microwave irradiation;

DOI:10.1002/ardp.201400192

Reference yield: 48.0%

3-chloro-aniline (108-42-9) → 1-amino-3-chlorobenzene-6-sulfonic acid (3479-10-5)

Guidance literature:

3-chloro-aniline; With sulfuric acid; at 85 ℃;

at 200 ℃; for 7h;

DOI:10.1021/jm030638w

upstream raw materials:

4-chloro-2-nitrobenzenesulfenyl chloride

3-chloro-aniline

bis(2-nitro-4-chlorophenyl)disulfide

thiophene

Downstream raw materials:

3-chloro-2,4,6-tribromoaniline

4-chloro-2-[(ethoxycarbonyl)amino]benzenesulfonyl chloride

4-chloro-2-{[5-(4-chloro-phenyl)-2-trifluoromethyl-furan-3-carbonyl]-amino}-benzene-sulfonic acid

2-((E)-3-biphenyl-4-yl-acryloylamino)-4-chloro-benzenesulfonic acid

Refernces

• 1、 Jagadeesh, Rajenahally V.,Sandhya, Y. Sree,Karthikeyan,Reddy, S. Sudhakar,Reddy, P. Pradeep Kumar,Kumar, M. Viniod,Charan, K. T. Prabhu,Narender,Bhagat. "The efficient palladium-catalyzed selective t synthesis of benzenesulfonic acids". experimental part. p. 2343 - 2349. Retrieved 2011/09/12.
• 2、 Valgeirsson, Jon,Nielsen, Elsebet ?.,Peters, Dan,Mathiesen, Claus,Kristensen, Anders S.,Madsen, Ulf. "Bioisosteric modifications of 2-arylureidobenzoic acids: Selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5". . p. 6948 - 6957. Retrieved 2007/10/03.