Technology Process of 2,6-dibromo-3,4,5-trimethoxytoluene
There total 3 articles about 2,6-dibromo-3,4,5-trimethoxytoluene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bromine; sodium acetate; acetic acid;
In
tetrachloromethane;
at 10 - 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1002/hlca.201200564
- Guidance literature:
-
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux
3: sodium acetate; acetic acid; bromine / tetrachloromethane / 2.5 h / 10 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); n-butyllithium; bromine; sodium acetate; sodium carbonate; acetic acid;
In
tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; water;
2: |Suzuki-Miyaura Coupling;
DOI:10.1002/hlca.201200564
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux
2: sodium acetate; acetic acid; bromine / tetrachloromethane / 2.5 h / 10 - 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); bromine; sodium acetate; sodium carbonate; acetic acid;
In
tetrachloromethane; 1,2-dimethoxyethane; water;
1: |Suzuki-Miyaura Coupling;
DOI:10.1002/hlca.201200564
