(R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide

Base Information

• Chemical Name: (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide
• CAS No.: 1380503-46-7
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 1380503-46-7.mol

Synonyms:(R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide

Chemical Property of (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide

There total 12 articles about (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(R)-4-(dimethylcarbamoyl)-1-phenyl-2-butyl acetate → (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide (1380503-46-7)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 24h; optical yield given as %ee;

DOI:10.1002/ejoc.201101800

Reference yield: 50.0%

4-(dimethylcarbamoyl)-1-phenyl-2-butyl acetate (1380503-44-5) → (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide (1380503-46-7) + (S)-4-(dimethylcarbamoyl)-1-phenyl-2-butyl acetate (1380503-45-6)

Guidance literature:

With Candida rugosa lipase; In acetone; at 37 ℃; for 96h; pH=7; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer;

DOI:10.1002/ejoc.201101800

Reference yield: 14.0%

4-hydroxy-N,N-dimethyl-5-phenylpentanamide (924893-87-8) + Isopropenyl acetate (108-22-5) → (S)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide (924893-94-7) + (R)-4-(dimethylcarbamoyl)-1-phenyl-2-butyl acetate + (R)-4-hydroxy-N,N-dimethyl-5-phenylpentanamide (1380503-46-7)

Guidance literature:

With Pseudomonas cepacia lipase; In tert-butyl methyl ether; at 20 ℃; for 288h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/ejoc.201101800

upstream raw materials:

4-hydroxy-N,N-dimethyl-5-phenylpentanamide

Isopropenyl acetate

allylbenzene

(±)-5-benzyldihydrofuran-2(3H)-one