4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

Base Information

Chemical Name:4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester
CAS No.:863562-14-5
Molecular Formula:C₁₅H₁₇Cl₂F₄NO₂
Molecular Weight:390.205
Hs Code.:

4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid <i>tert</i>-butyl ester

Synonyms:4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

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Chemical Property of 4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

There total 4 articles about 4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

: 863562-14-5
4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0502182

Reference yield:

: 863562-10-1
tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate

: 863562-14-5
4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: LiCl / dimethylformamide / 20 °C

With dmap; triethylamine; lithium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0502182

Reference yield:

pentafluorobenzoylchloride: 2251-50-5
pentafluorobenzoylchloride

: 863562-14-5
4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / tetrahydrofuran / 2 h / 0 - 20 °C

2: 52 percent / N,N-dimethyl-acetamide / 84 h / 90 °C

3: Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: LiCl / dimethylformamide / 20 °C

With dmap; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm0502182