tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate

Base Information

• Chemical Name: tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate
• CAS No.: 863562-10-1
• Molecular Formula: C₁₅H₁₉F₄NO₄
• Molecular Weight: 353.314
• Mol file: 863562-10-1.mol

Synonyms:tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate

Chemical Property of tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate

There total 2 articles about tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2,2'-iminobis[ethanol] (111-42-2) + tert-butyl 2,3,4,5,6-pentafluorobenzoate (98040-93-8) → tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate (863562-10-1)

Guidance literature:

In N,N-dimethyl acetamide; at 90 ℃; for 84h;

DOI:10.1021/jm0502182

Reference yield:

pentafluorobenzoylchloride (2251-50-5) → tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate (863562-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / tetrahydrofuran / 2 h / 0 - 20 °C

2: 52 percent / N,N-dimethyl-acetamide / 84 h / 90 °C

In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1021/jm0502182

Reference yield:

tert-butyl 4-(bis(2-hydroxyethyl)amino)-2,3,5,6-tetrafluorobenzoate (863562-10-1) + Methanesulfonic anhydride (7143-01-3) → 4-[bis-(2-methanesulfonyloxy-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm0502182

upstream raw materials:

2,2'-iminobis[ethanol]

tert-butyl 2,3,4,5,6-pentafluorobenzoate

pentafluorobenzoylchloride

Downstream raw materials:

4-[bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetrafluoro-benzoic acid tert-butyl ester

tert-butyl 4-(bis(2-iodoethyl)amino)-2,3,5,6-tetrafluorobenzoate