[3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid

Base Information

• Chemical Name: [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid
• CAS No.: 1448316-84-4
• Molecular Formula: C₂₇H₂₂F₅N₅O₃S
• Molecular Weight: 591.561

Synonyms:[3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid

Chemical Property of [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid

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Technology Process of [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid

There total 12 articles about [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

methanol (67-56-1) + tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-83-3) → [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetic acid (1448316-84-4) + methyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-85-5)

Guidance literature:

tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

methanol; In 1,4-dioxane;

Reference yield: 39.0%

tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetate (1448316-83-3) → [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetic acid (1448316-84-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

1-(2,4-dimethyl-5-nitrophenyl)-6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazole (1448317-38-1) → [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(pentafluoro-λ6-sulphanyl)phenyl]acetic acid (1448316-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 2.5 h / Reflux

2: HATU; dmap / N,N-dimethyl-formamide / 3 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; dmap; palladium 10% on activated carbon; ammonium formate; HATU; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl [3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-carbamoyl)-5-(pentafluoro-λ⁶-sulphanyl)phenyl]acetate

methanol

nicotinoylacetonitrile

1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Downstream raw materials:

3-(2-amino-2-oxoethyl)-N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

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