Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester

Base Information

• Chemical Name: Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester
• CAS No.: 177084-33-2
• Molecular Formula: C₄₉H₉₃N₂O₆P
• Molecular Weight: 837.261

Synonyms:Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester

Chemical Property of Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester

Chemical Property:

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Technology Process of Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester

There total 1 articles about Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,2-dihexadecylglycerol (6076-35-3) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2) → Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester (177084-33-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1002/hlca.19960790210

Reference yield:

Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester (177084-33-2) → 3'-deoxy-N6,5'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<(2RS)-2,3-bis(hexadecyloxy)propyl 2-(4-nitrophenyl)ethyl phosphate> (177084-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / acetonitrile; CH₂Cl₂ / 1.5 h

2: I₂ / pyridine; H₂O; CH₂Cl₂; acetonitrile

With 1H-tetrazole; iodine; In pyridine; dichloromethane; water; acetonitrile;

DOI:10.1002/hlca.19960790210

Reference yield:

Diisopropyl-phosphoramidous acid 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester (177084-33-2) → 3'-deoxy-N6,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 5'-<(2RS)-2,3-bis(hexadecycloxy)propyl 2-(4-nitrophenyl)ethyl phosphate> (177084-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-tetrazole / acetonitrile; CH₂Cl₂ / 1.5 h

2: I₂ / pyridine; H₂O; CH₂Cl₂; acetonitrile

With 1H-tetrazole; iodine; In pyridine; dichloromethane; water; acetonitrile;

DOI:10.1002/hlca.19960790210

upstream raw materials:

1,2-dihexadecylglycerol

2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

Downstream raw materials:

3'-deoxy-N⁶,5'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 2'-<(2RS)-2,3-bis(hexadecyloxy)propyl 2-(4-nitrophenyl)ethyl phosphate>

3'-deoxy-N⁶,2'-O-bis<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 5'-<(2RS)-2,3-bis(hexadecycloxy)propyl 2-(4-nitrophenyl)ethyl phosphate>

Phosphoric acid (2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 2,3-bis-hexadecyloxy-propyl ester 2-(4-nitro-phenyl)-ethyl ester

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