1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol

Base Information

• Chemical Name: 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol
• CAS No.: 79850-99-0
• Molecular Formula: C₁₈H₂₈O₇
• Molecular Weight: 356.416
• Mol file: 79850-99-0.mol

Synonyms:1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol

Chemical Property of 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol

There total 5 articles about 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(2-methyl-1,3-dioxolan-2-yl)prop-1-yl magnesium bromide + 2,6-bis((2-methoxyethoxy)methoxy)benzaldehyde (79834-12-1) → 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol (79850-99-0)

Guidance literature:

In tetrahydrofuran;

DOI:10.1021/ja00413a018

Reference yield:

1,3-bis(methoxymethyl)resorcinol (57234-29-4) → 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol (79850-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / n-butyllithium / hexane; diethyl ether / 0.5 h / Ambient temperature

2: 87 percent / tetrahydrofuran

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ja00413a018

Reference yield:

recorcinol (108-46-3) → 1-(2,6-Bis-methoxymethoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-yl)-butan-1-ol (79850-99-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / sodium hydride / dimethylformamide / 3 h

2: 63 percent / n-butyllithium / hexane; diethyl ether / 0.5 h / Ambient temperature

3: 87 percent / tetrahydrofuran

With n-butyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;

DOI:10.1021/ja00413a018

upstream raw materials:

ethylene-cetal de la bromo-5 pentanone-2

2,6-bis((2-methoxyethoxy)methoxy)benzaldehyde

1,3-bis(methoxymethyl)resorcinol

recorcinol

Downstream raw materials:

3-Methoxymethoxy-9-methyl-8,13-dioxa-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-4-carboxylic acid phenylamide

C₂₄H₂₆O₉

(3,5-Dimethoxy-phenyl)-(4-hydroxymethyl-3-methoxymethoxy-9-methyl-8,13-dioxa-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-5-yl)-methanol

5-(3,5-Dimethoxy-benzoyl)-3-methoxymethoxy-9-methyl-8,13-dioxa-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-4-carbaldehyde