ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

Base Information

Chemical Name:ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate
CAS No.:1208330-91-9
Molecular Formula:C₂₂H₂₁ClN₂O₄
Molecular Weight:412.873
Hs Code.:

Synonyms:ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

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Chemical Property of ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

There total 9 articles about ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208330-89-5
ethyl 1-(4-chloro-2-methoxyphenyl)-2-(4-cyano-2-methylphenyl)-1H-pyrrole-3-carboxylate

: 1208330-91-9
ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: With water; dihydrogen peroxide; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1161274-19-6
4-cyano-2-methylbenzoyl chloride

: 1208330-91-9
ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: ozone / dichloromethane / 1 h / -78 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

5.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

With n-butyllithium; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; ozone; diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-46-7
ethyl 3-(4-cyano-2-methylphenyl)-3-oxopropanoate

: 1208330-91-9
ethyl 2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: ozone / dichloromethane / 1 h / -78 °C

3.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

4.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

With water; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; ozone; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; mineral oil;
DOI:10.1016/j.bmcl.2011.04.086