ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

Base Information

Chemical Name:ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate
CAS No.:105805-22-9
Molecular Formula:C₂₇H₂₄ClNO₅S
Molecular Weight:510.01
Hs Code.:

Synonyms:ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

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Chemical Property of ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

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Technology Process of ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

There total 6 articles about ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 105805-21-8
ethyl (7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)glyoxolate

: 29949-92-6
(chloromethylene)triphenylphosphorane

: 105805-22-9
ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

Guidance literature:: In tetrahydrofuran;
DOI:10.1039/c39860001062

Reference yield:

: 105805-16-1
1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone

: 105805-22-9
ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / dimethylsulfoxide / 55 °C

2: 72 percent / NaN₃, LiCl / dimethylformamide / 60 °C

3: 73 percent / SOCl₂, pyridine / 0 °C

4: 1,3,5-trimethyl-benzene / Heating

5: NaH / tetrahydrofuran

6: 79 percent / n-BuLi / 1,2-dimethoxy-ethane

7: 75 percent / tetrahydrofuran

With pyridine; n-butyllithium; thionyl chloride; sodium azide; sodium hydride; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene;
DOI:10.1039/c39860001062

Reference yield:

: 105805-17-2
2-(5'-benzyloxy-2'-bromophenyl)-2-methyl-oxirane

: 105805-22-9
ethyl 2-(7-benzyloxy-3-methyl-1-phenylsulphonyl-1H-indol-4-yl)-3-chloropropenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / NaN₃, LiCl / dimethylformamide / 60 °C

2: 73 percent / SOCl₂, pyridine / 0 °C

3: 1,3,5-trimethyl-benzene / Heating

4: NaH / tetrahydrofuran

5: 79 percent / n-BuLi / 1,2-dimethoxy-ethane

6: 75 percent / tetrahydrofuran

With pyridine; n-butyllithium; thionyl chloride; sodium azide; sodium hydride; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene;
DOI:10.1039/c39860001062