[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

Base Information

Chemical Name:[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol
CAS No.:607375-35-9
Molecular Formula:C₁₉H₂₂FNO₂
Molecular Weight:315.388
Hs Code.:

Synonyms:[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of [(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

There total 10 articles about [(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 607375-34-8
(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-oxopiperidin-3-carboxylic acid methyl ester

: 607375-35-9
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

Guidance literature:: With borane; In tetrahydrofuran; for 18h; Heating;
DOI:10.1021/ja0351692

Reference yield: 62.0%

: C₃₁H₃₅FN₂O₅

: 607375-35-9
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 20 ℃; for 3h; Schlenk technique;
DOI:10.1021/acs.joc.9b00320

Reference yield:

: 37155-08-1
1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one

: 607375-35-9
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

Guidance literature:: Multi-step reaction with 5 steps

1: Na₂CO₃ / CH₂Cl₂ / 0.5 h

2: 8.36 g / EtONa / ethanol / 0.5 h / Heating

3: 89 percent / CuCl₂; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h

4: 79 percent / MeOH; NaH / toluene / 4 h / Heating

5: 98 percent / BH₃ / tetrahydrofuran / 18 h / Heating

With methanol; borane; sodium ethanolate; sodium hydride; sodium carbonate; (R)-tol-BINAP; copper dichloride; sodium t-butanolate; tert-Amyl alcohol; In tetrahydrofuran; fluorobenzene; ethanol; dichloromethane; toluene;
DOI:10.1021/ja0351692