2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole

Base Information

• Chemical Name: 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole
• CAS No.: 1447031-61-9
• Molecular Formula: C₃₄H₂₅F₃N₂
• Molecular Weight: 518.581

Synonyms:2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole

Chemical Property of 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole

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Technology Process of 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole

There total 6 articles about 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-phenyl-1H-pyrrole (3042-22-6) + 1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol (1447004-27-4) → 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole (1447031-61-9)

Guidance literature:

With phosphorus pentoxide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201300212

Reference yield:

1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone (1447004-22-9) → 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole (1447031-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; sodium tetrahydroborate / methanol / 0.67 h

2: phosphorus pentoxide / dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; phosphorus pentoxide; sodium hydrogencarbonate; In methanol; dichloromethane;

DOI:10.1002/ejoc.201300212

Reference yield:

acetophenone oxime (613-91-2) → 2-[1,1-biphenyl]-4-yl-3-phenyl-5-[2,2,2-trifluoro-1-(5-phenyl-1H-pyrrol-2-yl)ethyl]-1H-pyrrole (1447031-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / Alkaline conditions

2: phosphorus pentoxide / dichloromethane / 16 h / 20 °C / Inert atmosphere

With phosphorus pentoxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/ejoc.201300212

upstream raw materials:

1-{5-[(1,1-biphenyl)-4-yl]-4-phenyl-1H-pyrrol-2-yl}-2,2,2-trifluoro-1-ethanone

2-phenyl-1H-pyrrole

1-(5-[1,1-biphenyl]-4-yl-4-phenyl-1H-pyrrol-2-yl)-2,2,2-trifluoro-1-ethanol

acetophenone oxime

Downstream raw materials:

4,4-difluoro-3-[(1,1-biphenyl)-4-yl]-2,5-diphenyl-8-trifluoromethyl-4-bora-3a,4a-diaza-s-indacene

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