2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

Base Information

Chemical Name:2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol
CAS No.:1201930-31-5
Molecular Formula:C₁₇H₁₂F₂N₆O
Molecular Weight:354.319
Hs Code.:

Synonyms:2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

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Chemical Property of 2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

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Technology Process of 2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

There total 6 articles about 2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201929-99-8
3-{[3-(5-bromopyrimidin-2-yl)phenyl]difluoromethyl}-6-methyl-1,2,4-triazolo[4,3-b]-pyridazine

: 1201930-31-5
2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

Guidance literature:: 3-{[3-(5-bromopyrimidin-2-yl)phenyl]difluoromethyl}-6-methyl-1,2,4-triazolo[4,3-b]-pyridazine; With potassium acetate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 80 ℃; for 18h;

With sodium peroxoborate tetrahydrate; In tetrahydrofuran; water; at 20 ℃; for 18h;

Reference yield:

: 885068-75-7
2-(3-bromophenyl)-2,2-difluoroacetic acid ethyl ester

: 1201930-31-5
2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 42 h / 80 - 90 °C / Inert atmosphere

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 66 h / 80 °C / Inert atmosphere

3.1: sulfuric acid / methanol / 24 h / 35 °C

4.1: hydrazine hydrate / methanol / 18 h / 45 °C

5.1: butan-1-ol / 18 h / 130 °C

6.1: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 18 h / 80 °C

6.2: 18 h / 20 °C

With hydrazine hydrate; sulfuric acid; potassium acetate; sodium carbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;

Reference yield:

: ethyl difluoro-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate

: 1201930-31-5
2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 66 h / 80 °C / Inert atmosphere

2.1: sulfuric acid / methanol / 24 h / 35 °C

3.1: hydrazine hydrate / methanol / 18 h / 45 °C

4.1: butan-1-ol / 18 h / 130 °C

5.1: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 18 h / 80 °C

5.2: 18 h / 20 °C

With hydrazine hydrate; sulfuric acid; potassium acetate; sodium carbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;