tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate
CAS No.:1201930-32-6
Molecular Formula:C₂₈H₃₁F₂N₇O₃
Molecular Weight:551.596
Hs Code.:

Synonyms:tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201930-31-5
2-{3-[difluoro(6-methyl-1,2,4-triazolo-[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-ol

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1201930-32-6
tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 885068-75-7
2-(3-bromophenyl)-2,2-difluoroacetic acid ethyl ester

: 1201930-32-6
tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 42 h / 80 - 90 °C / Inert atmosphere

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 66 h / 80 °C / Inert atmosphere

3.1: sulfuric acid / methanol / 24 h / 35 °C

4.1: hydrazine hydrate / methanol / 18 h / 45 °C

5.1: butan-1-ol / 18 h / 130 °C

6.1: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 18 h / 80 °C

6.2: 18 h / 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

With hydrazine hydrate; di-isopropyl azodicarboxylate; sulfuric acid; potassium acetate; sodium carbonate; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;

Reference yield:

: 1201930-25-7
[3-(5-bromopyrimidin-2-yl)phenyl]difluoroacetic acid

: 1201930-32-6
tert-butyl 4-(2-{3-[difluoro-(6-methyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methyl]phenyl}pyrimidin-5-yloxymethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / methanol / 24 h / 35 °C

2.1: hydrazine hydrate / methanol / 18 h / 45 °C

3.1: butan-1-ol / 18 h / 130 °C

4.1: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 18 h / 80 °C

4.2: 18 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

With hydrazine hydrate; di-isopropyl azodicarboxylate; sulfuric acid; potassium acetate; triphenylphosphine; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; butan-1-ol;