3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

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Chemical Name:3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea
CAS No.:1555701-59-1
Molecular Formula:C₂₅H₂₃BrF₃N₃O₃
Molecular Weight:550.375
Hs Code.:

Synonyms:3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

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Chemical Property of 3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

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Technology Process of 3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

There total 5 articles about 3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1555699-78-9
2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)aniline

: 35037-73-1
1-isocyanato-4-trifluoromethoxy-benzene

: 1555701-59-1
3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm5006226

Reference yield:

: 1555701-57-9
4-bromo-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-2,3-dihydro-1H-indole

: 1555701-59-1
3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; ammonium chloride / 1 h / 20 °C / Inert atmosphere

2: dichloromethane / 16 h / 20 °C / Inert atmosphere

With ammonium chloride; zinc; In dichloromethane;
DOI:10.1021/jm5006226

Reference yield:

: 6358-77-6
5-bromo-2-methoxyaniline

: 1555701-59-1
3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite / water / -10 °C / Inert atmosphere

2.1: sulfuric acid / ethanol / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 0.75 h / 0 - 20 °C / Inert atmosphere

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

4.1: zinc; ammonium chloride / 1 h / 20 °C / Inert atmosphere

5.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; sodium nitrite; In ethanol; dichloromethane; water; toluene; 2.1: |Fischer Indole Synthesis;
DOI:10.1021/jm5006226