(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester

Base Information

• Chemical Name: (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester
• CAS No.: 71953-00-9
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.445
• Mol file: 71953-00-9.mol

Synonyms:(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester

Chemical Property of (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester

There total 12 articles about (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-iodo-2,3,4-trimethoxy-benzene (25245-37-8) + (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester (282734-33-2) → (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester (71953-00-9) + (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(2',3',4'-trimethoxyphenyl)propionic acid tert-butyl ester (381222-47-5)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 0.5h;

Reference yield: 59.0%

p-nitrobenzene iodide (636-98-6) + (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester (282734-33-2) → (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester (71953-00-9) + (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-nitrophenyl)propionic acid tert-butyl ester (381222-37-3)

Guidance literature:

(2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester; With chloro-trimethyl-silane; zinc; In N,N-dimethyl-formamide; at 20 ℃;

p-nitrobenzene iodide; With tris-(o-tolyl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 50 ℃; for 4h;

DOI:10.1039/b103832j

Reference yield: 59.0%

5-iodo-1,2,3-trimethoxybenzene (25245-29-8) + (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester (282734-33-2) → (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propionic acid tert-butyl ester (71953-00-9) + (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3',4',5'-trimethoxyphenyl)propionic acid tert-butyl ester (381222-48-6)

Guidance literature:

(2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester; With chloro-trimethyl-silane; zinc; In N,N-dimethyl-formamide; at 20 ℃;

5-iodo-1,2,3-trimethoxybenzene; With tris-(o-tolyl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 50 ℃; for 4h;

DOI:10.1039/b103832j

upstream raw materials:

p-nitrobenzene iodide

(2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-iodopropionic acid tert-butyl ester

1-iodo-2,3,4-trimethoxy-benzene

5-iodo-1,2,3-trimethoxybenzene

Downstream raw materials:

Fmoc-alanine