7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Base Information

Chemical Name:7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one
CAS No.:160389-57-1
Molecular Formula:C₁₉H₁₉N₃O₃
Molecular Weight:337.378
Hs Code.:

Synonyms:7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

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Chemical Property of 7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

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Technology Process of 7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

There total 9 articles about 7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19745-72-3
ω-amino-4-hydroxyacetophenone hydrochloride

: 160389-57-1
7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 5 steps

1: dioxane; H₂O / 1 h

2: 1.) K₂CO₃; 2.) pyridine / 1.) MeOH, 40 deg C, 1.5 h; 2.) r.t., 2 h

3: 81 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.25 h / 0 °C

4: 230 mg / H₂ / 10percent Pd-C / methanol / 3 h / Ambient temperature

5: methanol / Ambient temperature

With pyridine; sodium tetrahydroborate; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1016/S0040-4020(01)85674-X

Reference yield:

: [2-(4-Hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid benzyl ester

: 160389-57-1
7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) K₂CO₃; 2.) pyridine / 1.) MeOH, 40 deg C, 1.5 h; 2.) r.t., 2 h

2: 81 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.25 h / 0 °C

3: 230 mg / H₂ / 10percent Pd-C / methanol / 3 h / Ambient temperature

4: methanol / Ambient temperature

With pyridine; sodium tetrahydroborate; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)85674-X

Reference yield:

: Acetic acid 4-(2-benzyloxycarbonylamino-acetyl)-phenyl ester

: 160389-57-1
7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NaBH₄ / methanol; CH₂Cl₂ / 0.25 h / 0 °C

2: 230 mg / H₂ / 10percent Pd-C / methanol / 3 h / Ambient temperature

3: methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)85674-X