19745-72-3

Basic information

• Product Name: 4-hydroxy-alpha-aminoacetophenone
• Synonyms: 4-hydroxy-alpha-aminoacetophenone;Ethanone, 2-aMino-1-(4-hydroxyphenyl)-, hydrochloride;2-AMino-4'-hydroxy-acetophenone HCl;4-hydroxy-α-aMinoacetophenonehcl
• CAS NO: 19745-72-3
• Molecular Formula: C8H9NO2.ClH
• Molecular Weight: 187.625
• Mol File: 19745-72-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 249–251°C
• Boiling Point: 351.4°Cat760mmHg
• Flash Point: 166.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.02E-05mmHg at 25°C
• CAS DataBase Reference: 4-hydroxy-alpha-aminoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-alpha-aminoacetophenone(19745-72-3)
• EPA Substance Registry System: 4-hydroxy-alpha-aminoacetophenone(19745-72-3)

Safety Data

• Hazardous Substances Data: 19745-72-3(Hazardous Substances Data)

Usage

Preparation

Obtained by treatment of a-bromo-4-hydroxyacetophenone with hexamethylenetetramine in chloroform at r.t. for 1 h.

InChI:InChI=1/C8H9NO2.ClH/c9-5-8(11)6-1-3-7(10)4-2-6;/h1-4,10H,5,9H2;1H

Upstream product

• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 108-95-2 phenol 
• 77369-38-1 2-amino-1-(4-hydroxyphenyl)ethyl ketone 

Downstream Products

• 877387-18-3 C₁₈H₁₈N₂O₅ 
• 877386-94-2 C₂₈H₂₉N₃O₉ 
• 156-38-7 4-hydroxyphenylacetate 
• 108791-64-6 1,4-bis(4-hydroxyphenyl)butan-1,4-dione 
• 99-93-4 4-Hydroxyacetophenone 
• 12125-02-9 ammonium chloride 
• 60-19-5 tyramine hydrochloride 
• 1416548-69-0 4-chloro-N-(4-((1-((2-(4-hydroxyphenyl)-2-oxoethyl)amino)-2-methyl-1-oxopropan-2-yl)oxy)phenethyl)benzamide 
• 1416548-73-6 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide 
• 1416548-71-4 2-(4-(4-chlorobenzoyl)phenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2-methylpropanamide 
• 1416548-75-8 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2-methylpropanamide 
• 130017-92-4 2,5-bis-(4-acetoxy-phenyl)-pyrazine 
• 16877-75-1 4,4'-pyrazine-2,5-diyl-bis-phenol 
• 160389-57-1 7-<<2-hydroxy-2-(4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one 

Relevant articles and documents

Synthetic method for tyramine hydrochloride

The invention discloses a synthetic method for tyramine hydrochloride. The synthetic method includes the steps that phenol is used as a raw material and reacts with aminoacetonitrile to generate p-hydroxy phenylaminoethanol, p-hydroxy phenylaminoethanol is subjected to catalytic reduction to obtain tyramine hydrochloride, activated carbon and copper powder are used as a composite catalyst, and the mass ratio of the activated carbon to the copper powder is (3-5):1. As the activated carbon and copper powder composite catalyst is added, the ratio of the dosage of the catalyst to the substrate weight can be reduced to (0.1-0.2):1. The catalytic efficiency is improved remarkably, the number of times of continuously using the catalyst can be increased to be 10 or more, the total yield of the reactions is increased, and the synthetic method has high economic benefits.

Discovery and synthesis of a novel series of liver X receptor antagonists

Fourteen novel compounds were prepared and their antagonistic activities against liver X receptors (LXR) α/β were tested in vitro. Compound 26 had an IC50 value of 6.4 μM against LXRα and an IC50 value of 5.6 μM against LXRβ. Docking studies and the results of structure-activity relationships support the further development of this chemical series as LXRα/β antagonists.