5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine

Base Information

• Chemical Name: 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine
• CAS No.: 40094-22-2
• Molecular Formula: C₃₄H₃₆N₆O₆
• Molecular Weight: 624.696

Synonyms:5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine

Chemical Property of 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine

Chemical Property:

Purity/Quality:

98%, ^*data from raw suppliers

2'-Deoxy-N2-DMF-5'-O-DMT-guanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine

There total 3 articles about 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2-dimethylaminomethylene-2'-deoxyguanosine (17331-13-4) → 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine (40094-22-2)

Guidance literature:

With pyridine;

DOI:10.1016/S0040-4039(00)61075-4

Reference yield:

2'-Deoxyguanosine (961-07-9) → 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine (40094-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / Ambient temperature

2: 82 percent / pyridine

With pyridine; In methanol;

DOI:10.1016/S0040-4039(00)61075-4

Reference yield:

→ 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-2'-deoxy-N-[(dimethylamino)methylene]guanosine (40094-22-2)

Guidance literature:

N(2)Dimethylaminomethylen-2'-desoxyguanosin,Bis-(4-methoxyphenyl)phenylmethylchlorid;

upstream raw materials:

4,4'-dimethoxytrityl chloride

N²-dimethylaminomethylene-2'-deoxyguanosine

2'-Deoxyguanosine

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

1,8-diazabicyclo[5.4.0]undec-7-enium 5'-O-(4,4'-dimethoxytrityl)deoxyguanosin-3'-yl phosphonate

C₃₄H₃₇N₆O₈P*C₉H₁₆N₂

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