N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE

Base Information

Chemical Name:N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
CAS No.:330628-04-1
Molecular Formula:C43H53N8O7P
Molecular Weight:824.917
Hs Code.:29349990
Mol file:330628-04-1.mol

Synonyms:DMT-dG(dmf) amidite;N2-(dimethylamino)methylene-deoxyguanosine Phosphoramidite;(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-((E)-(dimethylamino)methyleneamino)-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite;REF DUPL;DMF-dG-CE-Phophoramidite;N4-(Dimethylamino) methylene)-5'-O-(dimethoxytrityl)-2'-deoxyguanosine-3'-N,N-diisopropyl(cyanoethyl) phosphoramidite;

Suppliers and Price of N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dmf-dG-CEPhosphoramidite
250mg
$ 40.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite configured for MerMade
6x10g
$ 1980.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite ≥99% (31P-NMR)
1kg
$ 15080.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite ≥99% (31P-NMR)
500g
$ 9730.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite ≥99% (31P-NMR)
6x20g
$ 1350.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite configured for ABI
12x3g
$ 1270.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite configured for ABI
12
$ 389.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite ≥99% (31P-NMR)
100g
$ 1060.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite configured for MerMade
6x5g
$ 1050.00

Sigma-Aldrich
DMT-dG(dmf) Phosphoramidite configured for ABI, configured for (KTA
6x5g
$ 1020.00

Total 40 raw suppliers

Chemical Property of N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE

Chemical Property:

Boiling Point:876.3±75.0 °C(Predicted)
PKA:3.80±0.20(Predicted)
PSA：175.17000
LogP:7.31558
Storage Temp.:?20°C

Purity/Quality:

99% ^*data from raw suppliers

Dmf-dG-CEPhosphoramidite ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE

There total 4 articles about N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 961-07-9
2'-Deoxyguanosine

: 330628-04-1
5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: methanol

2: 78 percent / pyridine

3: diisopropylammonium tetrazolide

With pyridine; N,N-diisopropylamine tetrazolide; In methanol;
DOI:10.1016/S0040-4039(00)88541-X

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 330628-04-1
5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine

2: diisopropylammonium tetrazolide

With pyridine; N,N-diisopropylamine tetrazolide;
DOI:10.1016/S0040-4039(00)88541-X

Reference yield:

: 17331-13-4
N²-dimethylaminomethylene-2'-deoxyguanosine

: 330628-04-1
5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine

2: diisopropylammonium tetrazolide

With pyridine; N,N-diisopropylamine tetrazolide;
DOI:10.1016/S0040-4039(00)88541-X