4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate

Base Information

• Chemical Name: 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate
• CAS No.: 1196666-36-0
• Molecular Formula: C₁₇H₁₅NO₅
• Molecular Weight: 313.31
• Mol file: 1196666-36-0.mol

Synonyms:4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate

Chemical Property of 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate

There total 1 articles about 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(4-methoxyphenyl)((1S,2S)-(Z)-1-nitro-2-phenylcyclopropyl)methanone (1196665-93-6) → 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate (1196666-36-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; isopropyl alcohol; at 47 ℃; for 16h; pH=7.5; aq. phosphate buffer;

DOI:10.1021/ja9044955

Reference yield: 96.0%

methanol (67-56-1) + 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate (1196666-36-0) → methyl (1S,2S)-1-nitro-2-phenylcyclopropanecarboxylate (1095278-82-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja201237j

Reference yield: 93.0%

1-indoline (496-15-1) + 4-methoxyphenyl-(1S,2S)-(Z)-1-nitro-2-phenylcyclopropanecarboxylate (1196666-36-0) → 4-(methyloxy)phenyl (4R)-4-(2,3-dihydro-1H-indol-1-yl)-2-nitro-4-phenylbutanoate (1309588-56-4)

Guidance literature:

With nickel(II) perchlorate hexahydrate; In dichloromethane; at 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ja201237j

upstream raw materials:

(4-methoxyphenyl)((1S,2S)-(Z)-1-nitro-2-phenylcyclopropyl)methanone

Downstream raw materials:

4-methoxyphenyl-(1S,2S)-(Z)-1-amino-2-phenylcyclopropanecarboxylate

methyl (1S,2S)-1-nitro-2-phenylcyclopropanecarboxylate

4-(methyloxy)phenyl (4R)-4-(2,3-dihydro-1H-indol-1-yl)-2-nitro-4-phenylbutanoate

4-(methyloxy)phenyl (1S,2S)-2-phenyl-1-[(phenylcarbonyl)amino]cyclopropanecarboxylate