dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

Base Information

• Chemical Name: dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate
• CAS No.: 1342891-85-3
• Molecular Formula: C₂₈H₂₇NO₇S
• Molecular Weight: 521.591
• Mol file: 1342891-85-3.mol

Synonyms:dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

Chemical Property of dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

There total 1 articles about dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

dimethyl 3-phenyl-1-tosylaziridine-2,2-dicarboxylate (1132667-77-6) + 4-methoxyphenylacetylen (768-60-5) → dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate (1342891-85-3)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ol202603e

Reference yield: 85.0%

dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate (1342891-85-3) → dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosylpyrrolidine-2,2-dicarboxylate

Guidance literature:

With palladium on activated charcoal; hydrogen; In tetrahydrofuran; at 60 ℃; optical yield given as %de;

DOI:10.1021/ol202603e

Reference yield: 65.0%

dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate (1342891-85-3) → methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5)

Guidance literature:

With sodium chloride; In water; dimethyl sulfoxide; at 160 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol202603e

upstream raw materials:

dimethyl 3-phenyl-1-tosylaziridine-2,2-dicarboxylate

4-methoxyphenylacetylen

Downstream raw materials:

methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate