methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate
• CAS No.: 943817-28-5
• Molecular Formula: C₁₉H₁₇NO₃
• Molecular Weight: 307.349
• Mol file: 943817-28-5.mol

Synonyms:methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate

Chemical Property of methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate

There total 4 articles about methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate (1342891-85-3) → methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5)

Guidance literature:

With sodium chloride; In water; dimethyl sulfoxide; at 160 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol202603e

Reference yield:

(E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) + (E)-N-benzylideneglycine methyl ester (66646-88-6,120238-40-6,138495-05-3) → methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5) + 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole (943817-27-4)

Guidance literature:

(E)-1-methoxy-4-(2-nitrovinyl)benzene; (E)-N-benzylideneglycine methyl ester; With silver(I) acetate; triethylamine; In acetonitrile; at 20 ℃;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In xylene; at 100 ℃; for 0.75h; Microwave irradiation;

Reference yield:

(2S,3R,4S,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate (888330-67-4) + (2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate (888330-57-2) → methyl 3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxylate (943817-28-5) + 5-phenyl-3-(4-methoxyphenyl)-2-methoxycarbonyl-4-nitro-1H-pyrrole (943817-27-4)

Guidance literature:

With manganese(IV) oxide; In diethylene glycol dimethyl ether; for 48h; Heating / reflux;

upstream raw materials:

(2S,3R,4S,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

(2S,3S,4R,5S)-methyl 3-(4-methoxyphenyl)-4-nitro-5-phenylpyrrolidine-2-carboxylate

dimethyl 3-(4-methoxyphenyl)-5-phenyl-1-tosyl-1H-pyrrole-2,2(5H)-dicarboxylate

4-methoxyphenylacetylen

Downstream raw materials:

5-phenyl-3-(4-methoxyphenyl)-4-nitro-1H-pyrrole-2-carboxylic acid

N-(6-(hydroxyamino)-6-oxohexyl)-3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamide

methyl 6-[3-(4-hydroxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate

methyl 6-[3-(4-methoxyphenyl)-5-phenyl-1H-pyrrole-2-carboxamido] hexanoate