Technology Process of 2,3,5,6-Tetrafluoro-alpha-phenylbenzenemethanol
There total 4 articles about 2,3,5,6-Tetrafluoro-alpha-phenylbenzenemethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,2,4,5-Tetrafluorobenzene;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
Glovebox;
Schlenk technique;
Inert atmosphere;
benzaldehyde;
In
tetrahydrofuran;
at 20 ℃;
Glovebox;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.joc.5b02022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4,4'-di-tert-butyl-2,2'-bipyridine; C10H18IrO2 / hexane / 48 h / 20 °C / Glovebox; Sealed tube; Inert atmosphere
2: potassium carbonate / toluene / 48 h / 80 °C / Glovebox; Inert atmosphere; Sealed tube
With
C10H18IrO2; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine;
In
hexane; toluene;
DOI:10.1002/anie.202103686
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 78 percent / lithium aluminum hydride / tetrahydrofuran / 7 h / Ambient temperature
2: 1.) tris(diethylamino)sulfonium difluorotrimethylsilicate; 2.) 1 M hydrochloric acid / 1.) THF, 0 deg C, 12 h; 2.) room temperature, methanol
With
hydrogenchloride; lithium aluminium tetrahydride; tris(diethylamino)sulfonium difluorotrimethylsiliconate;
In
tetrahydrofuran;
DOI:10.1016/S0040-4020(01)86661-8
