tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate
CAS No.:1192189-67-5
Molecular Formula:C₂₉H₃₈N₄O₇
Molecular Weight:554.643
Hs Code.:

Synonyms:tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

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Technology Process of tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₇ClN₂O₅

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-67-5
tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: With pyridine; In dichloromethane; Cooling with ice;

Reference yield:

: 1192189-66-4
4-[(benzyloxycarbonylamino)methyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

: 19962-04-0
Dimethylcarbaminsaeure-3-aminophenylester

: 1192189-67-5
tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: 4-[(benzyloxycarbonylamino)methyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid; With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;

Dimethylcarbaminsaeure-3-aminophenylester; In dichloromethane; Inert atmosphere; Cooling with ice;
DOI:10.1021/ml500367g

Reference yield:

: 362703-35-3
1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

: 1192189-67-5
tert-butyl 4-[(benzyloxycarbonylamino)methyl]-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 50 °C / Inert atmosphere

2.2: pH 5 / Inert atmosphere

3.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3.2: Inert atmosphere; Cooling with ice

With pyridine; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ml500367g