1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate
CAS No.:1192189-65-3
Molecular Formula:C₂₁H₃₀N₂O₆
Molecular Weight:406.479
Hs Code.:

Synonyms:1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

There total 1 articles about 1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 362703-35-3
1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1192189-65-3
1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 1192189-65-3
1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

: 1192189-66-4
4-[(benzyloxycarbonylamino)methyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid

Guidance literature:: 1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate; With water; sodium hydroxide; In methanol; at 50 ℃;

With hydrogenchloride; In methanol; water; pH=5;

Reference yield:

: 1192189-65-3
1-tert-butyl 4-methyl 4-[(benzyloxycarbonylamino)methyl]piperidine-1,4-dicarboxylate

: 1192189-64-2
3-{4-[(benzyloxycarbonylamino)methyl]piperidine-4-carboxamido}phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 50 °C / Inert atmosphere

1.2: pH 5 / Inert atmosphere

2.1: pyridine; oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

2.2: Inert atmosphere; Cooling with ice

3.1: hydrogenchloride; methanol / 1,4-dioxane / 1 h / 50 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 120 °C / Inert atmosphere; High pressure

With pyridine; hydrogenchloride; methanol; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml500367g